OFFICE HOUR:
Monogenic diseases
polygenic what would they look like in the pedigree
two genes homework
example of two traits in the pedigree
three point crosses
three genes map them for drosiphila
coeffinient of map units
interference strength
centromere inhibit cross over opposite of centromere
no chi square
• centromere inhibit cross over
inhibit crossing over between them – closer together
Dna preventing from the normal amount of crossover
distinction between the physical map and the genetic map
not always the same
how mayn letter between these letter
how much cross over happened in these genes
use the genetic map to imply the physical map
over 50 physical map units
70 ph apart how much recombination( 50%)
50 or greater independent
physically linkend but not genetically linked
certain part of chromosomes more than you expect
some DNA doesn’t cross over that much
each human is couple of physical map
chromosome 1 2 3 800 map units
prions tertiary form
sporatic CJD
primary –
seconday X alpha sheet
tertiary huge difference in the structure
FFI all of the above ( same gene PRNP human gene) specific mutant allele
varient / seconday and tertiary
sporatic goes to abnomal without environmental
enviromental factors
CDC
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