Wednesday, May 28, 2008
NOTICE
Scott's Resources
Just a reminder that we have a (completely optional!) lecture tonight. Topics I'll try to cover include SNP genotyping (as in, how do they figure out which SNPs you have?), some cloning, and the use of enhancer traps, a technique we briefly discussed in the material on Fbx15. Again, the lecture is optional, and will not affect your grade. I will not have the final exams to pass back... if you want your final exam returned, I will pass them back in the second week of the 355 course I run in the summer. Semester grades should be complete by this Friday.
A few other things... Some have asked for good sources of information on biology. I would recommend sciencedaily.com, which does an excellent job of explaining complicated research findings in a comprehensible way.
I would also suggest a subscription to Science magazine, one of the preeminent science journals in the world. The magazine provides both original research papers and multiple reviews that are accessible to "non-experts".
https://pubs.aaas.org/org_membership/new_member_setup.asp
An undergraduate subscription is $75 a year, only $1.50 per weekly issue... less than half the cost of a venti latte at Starbucks.
Finally, if you haven't registered to vote in the fall, it is VERY easy to do... the form, which takes five minutes to complete, is online.
http://www.sos.ca.gov/elections/elections_vr.htm
The only way that issues which are important to you will be addressed is if you VOTE. Go register! Do it! :)
Have a great summer,
-sw
Saturday, April 19, 2008
Histology Notes 4/17/08
HISTOLOGY THURSDAY 4/17
Three gland adrenal thyroid and panrcreas
adrenal gland ( suprarenal gland) endocrine gland
two glands in one ( gland in center – medulla) edge-cortext separate endocrine glands
hormones they secrete is very different
Adrenal medulla ( Epinephrine (20%)/NeuroEpi(80%))
alpha and beta receptors ( heart Beta Recetor ( epinephrine) increase H.R. and contractibility
cortex secretes steroids equal amounts in females and males
steroids- Mineralocorticoides (aldosterone)→ regulates kidney increase Na reabor and sodium excretion
glucocorticoide ( cortisol/ corticosterone)
sex hormones ( all steroids)
different types → androgen( increase sex character)
CT capsule outside covering with dots
cortex three zone middle is the largest very verticles
medullary cords
cells of 2/3 of cortex
notice the circulation vessels coming into the surface
figure 20-11
hormones from the cortex pass through the medulla
medullary artery
tropic hormone ( stimulate other hormones-anterior pituitary)
receptors for the ACTH peptide ( surface receptor) signal transduction and the cell makes steroid.
cortisol negatively feed back ( only)
inhibits ACTH
aldosterone →kidney salt sweet in the middle like insulin (cortisol) plasma glucose
androgen as the
figure 20-15
disease s
hyposecretion( ectomy removal) hypophosectomy ( atrophy) smaller
stress → activity of the cortex
medulla different kind of cell
no T. M.
Rough ER, Golgi present
secretory granules.
no stored hormones in cortext
tyrosine ( transporter)
hormones
stimulus for releasing hormones( sympapathic) preganglionic cell
cholinergic nerve ending
postganglinic neuron cell by itself
THYROID
infront of the treacha
adam’s apple
along the trachea
palate very soft
can be check for cancer- arise in the thyroid often
gland itself when radiated ( radioactive I) can cause cancer
parathyroid( posterior) four bundle of the tissue
very well vascularized
ball of cells- follicles
pars intermedia of the pituitary
entire gland is made up of follicles
Colloid (describe protein)
parafollicular cells along side of the follicles (T3-T4)
para- Calcitonin ( lowers ca2+)
PTH( parathyroid hormone raises plasma calcium)
Thyroid diseases ( graves disease) well known hyperthyroidism autoimmune disease- auto anti-bodies stimulating the thyroid gland as if they were pitatary hormone ( TSH)
more T3 and T4 increase in follicular growth
Pathology ( Hashimoto’s thyroditis autoimmune hypothyroidism
follicle rising in the tissue massive inflammation of thyroids
synthesis- follicular cells colloid is on top
starting is amino acids (fig20-27)
hormone exocytose in the
thyroglobulin
when the cel
cleavage of the large protein
puts them together T3 and T4(four iodides tyrosine)
parathyroid glands
laryngeal nerve (thyroid cancer)
prevention of phonation( speaking)
brown deposit of sec reaction calcitonin positive (parafollicular cells)
PANCREAS
B cells insulin
A cell glucogon