Wednesday, May 28, 2008

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HISTOLOGY LAB




QUESTIONS, COMMENTS PLEASE EMAIL

Srostamm@yahoo.com

WC-101



Manhattan, MSG



The Iranian- Firouz Naderi, Ph.D. A NASA Scientist

http://www.searchles.com/links/show/id/323860

Scott's Resources

Hi all,

Just a reminder that we have a (completely optional!) lecture tonight.  Topics I'll try to cover include SNP genotyping (as in, how do they figure out which SNPs you have?), some cloning, and the use of enhancer traps, a technique we briefly discussed in the material on Fbx15.  Again, the lecture is optional, and will not affect your grade.  I will not have the final exams to pass back... if you want your final exam returned, I will pass them back in the second week of the 355 course I run in the summer.  Semester grades should be complete by this Friday.

A few other things...  Some have asked for good sources of information on biology.  I would recommend sciencedaily.com, which does an excellent job of explaining complicated research findings in a comprehensible way.  

I would also suggest a subscription to Science magazine, one of the preeminent science journals in the world.  The magazine provides both original research papers and multiple reviews that are accessible to "non-experts".  

https://pubs.aaas.org/org_membership/new_member_setup.asp

An undergraduate subscription is $75 a year, only $1.50 per weekly issue... less than half the cost of a venti latte at Starbucks.

Finally, if you haven't registered to vote in the fall, it is VERY easy to do... the form, which takes five minutes to complete, is online.

http://www.sos.ca.gov/elections/elections_vr.htm

The only way that issues which are important to you will be addressed is if you VOTE.  Go register!  Do it!  :)

Have a great summer,
-sw

Saturday, April 19, 2008

Histology Notes 4/17/08

HISTOLOGY THURSDAY  4/17

Three gland adrenal thyroid and panrcreas

adrenal gland ( suprarenal gland) endocrine gland

two glands in one ( gland in center – medulla) edge-cortext separate endocrine glands

hormones they secrete is very different

Adrenal medulla ( Epinephrine (20%)/NeuroEpi(80%))

alpha and beta receptors ( heart Beta Recetor ( epinephrine) increase H.R. and contractibility

cortex secretes steroids equal amounts in females and males

 

steroids- Mineralocorticoides (aldosterone)→ regulates kidney increase Na reabor and sodium excretion

 

glucocorticoide ( cortisol/ corticosterone)

sex hormones ( all steroids)

different types → androgen( increase sex character)

 

CT capsule outside covering with dots

cortex three zone middle is the largest very verticles

medullary cords

cells of 2/3 of cortex

notice the circulation vessels coming into the surface

figure 20-11

hormones from the cortex pass through the medulla

medullary artery

tropic hormone ( stimulate other hormones-anterior pituitary)

receptors for the ACTH peptide ( surface receptor) signal transduction and the cell makes steroid.

cortisol negatively feed back ( only)

inhibits ACTH

aldosterone →kidney salt sweet in the middle like insulin (cortisol) plasma glucose

androgen as the

figure 20-15

disease s

hyposecretion( ectomy removal) hypophosectomy ( atrophy) smaller

stress → activity of the cortex

 

medulla different kind of cell

no T. M.

Rough ER, Golgi present

secretory granules.

no stored hormones in cortext

tyrosine ( transporter)

hormones

stimulus for releasing hormones( sympapathic) preganglionic cell

cholinergic nerve ending

postganglinic neuron cell by itself

 

THYROID

infront of the treacha

adam’s apple

along the trachea

palate very soft

can be check for cancer- arise in the thyroid often

gland itself when radiated ( radioactive I) can cause cancer

parathyroid( posterior) four bundle of the tissue

very well vascularized

ball of cells- follicles

pars intermedia of the pituitary

entire gland is made up of follicles

Colloid (describe protein)

parafollicular cells along side of the follicles (T3-T4)

para- Calcitonin ( lowers ca2+)

PTH( parathyroid hormone raises plasma calcium)

Thyroid diseases ( graves disease) well known hyperthyroidism autoimmune disease- auto anti-bodies stimulating the thyroid gland as if they were pitatary hormone ( TSH)

more T3 and T4 increase in follicular growth

 

Pathology ( Hashimoto’s thyroditis autoimmune hypothyroidism

follicle rising in the tissue massive inflammation of thyroids

synthesis- follicular cells colloid is on top

starting is amino acids (fig20-27)

hormone exocytose in the

thyroglobulin

when the cel

cleavage of  the large protein

puts them together T3 and T4(four iodides tyrosine)

parathyroid glands

laryngeal nerve (thyroid cancer)

prevention of phonation( speaking)

brown deposit of sec reaction calcitonin positive (parafollicular cells)

 

PANCREAS

B cells insulin

A cell glucogon

USMLE step 1

Provided by Foad N.

More Histology

Click here for more histology 
provided by Paul L.